Publications

(*equal contribution)

2026

Cao, H., Fu, Y., Zhou, X., Duan, Y., Ip, F. C. F., Chen, Y., Hu, S., Liu, S.C., Kwok, T. C. Y., Mok, K. Y., Cheung, T. H., Hardy, J., Fu, A. K., & Ip, N. Y. (2026). Genome-wide analysis of common structural variants in Alzheimer’s disease identifies a risk-associated regulatory CCG repeat in FAM193B. Nature Neuroscience.
Thomassen, J. Q., Leonard, H., Ulms, B., Grenier-Boley, B., Heikkinen, S., Garcia-González, P., Castillo-Morales, A., Kikuchi, M., Gim, J., Cao, H., … Frikke-Schmidt, R. (2026). APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease. Nature Genetics.
Wong, H. Y., Jin, C., Yuen, S. L., Yang, X., Gill, S. S., Xu, J., Lai, K. P. E., Fu, W.-Y., Gao, W., Wang, X., Wang, J., Cao, H., Lv, G., Mok, K. Y., Tian, R., Fu, A. K. Y., Chen, H., & Ip, N. Y. (2026). DeepPlaque: A scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer’s disease. EMBO Molecular Medicine.
Cao, H., Zheng, Z., Zhou, X. , Kikuchi, M., … Ip, N. Y. (2026). Ethnic-specific effects of the LILRB2–LILRB5 locus and newly identified risk loci for Alzheimer’s disease in the East Asian population. Alzheimer’s & Dementia.

Nicolas, A., Sherva, R., Grenier-Boley, B., Kim, Y., Kikuchi, M., Timsina, J., de Rojas, I., Dalmasso, M. C., Zhou, X., … Cao, H., Ip, N. Y., … Lambert, J.-C. (2025). Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations. Nature Genetics.
Liu, S. K., Cao, H., Yang, X., Zhou, X., Chen, Y., Fu, W.-Y., Chan, S. Y., Ip, F. C., Mok, K. Y., Mok, V. C., Kwok, T. C., Hardy, J., Fu, A. K., & Ip, N. Y. (2025). An ABCA1 missense variant decreases cholesterol efflux and confers Alzheimer’s disease risk in the Chinese population. Journal of Alzheimer’s Disease.

Zhou, X.*, Cao, H.*, Jiang, Y., Chen, Y., Zhong, H., … Ip, N. Y. (2024). Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer’s disease. Alzheimer’s & Dementia.
Zhong, H., Zhou, X., Uhm, H., Jiang, Y., Cao, H., … Ip, N. Y. (2024). Using blood transcriptome analysis for Alzheimer’s disease diagnosis and patient stratification. Alzheimer’s & Dementia.

Zhou, X., Chen, Y., Ip, F. C., Jiang, Y., Cao, H., Lv, G., … Ip, N. Y. (2023). Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction. Communications Medicine.

Cao, H., Zhou, X., Chen, Y., Ip, F. C. F., Chen, Y., … Ip, N. Y. (2022). Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk. Journal of Alzheimer’s Disease.

Ye, T., Duan, Y., Tsang, H. W. S., Xu, H., Chen, Y., Cao, H., Chen, Y., Fu, A. K. Y., & Ip, N. Y. (2021). Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Communications Biology.

Lau, S. F., Cao, H., Fu, A. K., & Ip, N. Y. (2020). Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America.